FOXM1 乳腺外Paget病的新治疗靶点论论

2305 Gene ResultFOXM1 forkhead box M1 human

Frequent FOXA1 Activating Mutations in Extramammary Paget s

In this study we investigated the role of forkhead box M1 FOXM1 a potent transcription factor in EMPD and assessed the potential of FOXM1 as a therapeutic target Immunohistochemistry of 112 primary and 17 metastatic EMPD samples revealed that FOXM1 expression increased with tumor progression

Current Management and Treatment of Extramammary Paget s Disease

It is suggested that FOXM1 is a promising therapeutic target for patients with EMPD after finding high expression of FOXM1 in in vitro studies using the newly established EMPD cell line KS EMPD 1

Extramammary Paget 39 s disease Updates in the workup and

Extramammary Paget disease EMPD is a rare skin cancer that primarily affects older individuals predominantly in areas with apocrine sweat glands Although most early EMPD lesions are indolent patients with metastatic EMPD have a poor prognosis due to the lack of effective systemic treatment In this study we investigated the role of forkhead box M1 FOXM1 a potent transcription factor

Foxm1 A New Therapeutic Target Of Extramammary Paget Disease

KS EMPD 1 cells and NHEKs were incubated with DMSO 0 1 or various concentrations of thiostrepton 0 25 10 0 μM for 72 h and evaluated for the number of viable cells using a formazan based

In this study we investigated the role of forkhead box M1 FOXM1 a potent transcription factor in EMPD and assessed the potential of FOXM1 as a therapeutic target Immunohistochemistry of

Using ChIP qPCR we showed that DRP1 modulates FOXM1 expression which can enhance MMP12 transcription by binding to its promoter We also showed that miR 575 could target 3 UTR of DRP1 mRNA and suppress DRP1 expression

FOXM1 a new therapeutic target of extramammary Paget disease

在这项研究中研究人员调查了一种称为forkhead box M1 FOXM1 的转录因子在EMPD中的作用并评估了FOXM1作为治疗靶点的潜力通过对112个初级和17个转移性EMPD样本进行免疫组化分析发现FOXM1表达随着肿瘤进展而增加

We performed a comprehensive genetic analysis or targeted gene sequencing in 48 patients with EMPD We identified FOXA1 mutations a GAS6 FOXA1 fusion gene and somatic hotspot mutations in the FOXA1 promoter region in 11 of the 48 EMPD patients 11 48 23

Foxm1 A New Therapeutic Target Of Extramammary Paget Disease Image Results

DRP1 contributes to head and neck cancer progression and

Controlled FOXM1 expression and activity provides a balanced transcriptional programme to ensure proper growth and maturation during embryogenesis and foetal development as well as to manage appropriate homeostasis and repair of adult tissues

Extramammary Paget 39 s disease EMPD is a rare cutaneous malignant disease Due to its rarity there is a paucity of data regarding best treatment strategy EMPD primarily affects apocrine gland bearing skin areas such as the vulva scrotum and penis

FOXM1 a new therapeutic target of extramammary Paget disease

KS EMPD 1 is sensitive to a FOXM1 inhibitor ResearchGate

Foxm1 A New Therapeutic Target Of Extramammary Paget Disease

FOXM1 a new therapeutic target of extramammary Paget disease

FoxM1 is a promising candidate target in the treatment of

FoxM1 was a potential biomarker for prognosis prediction and a promising therapeutic target in human solid tumors Through analysis of a broad spectrum of pooled datasets we found that FoxM1was significantly overexpressed in breast cancer comparing with normal breast tissue

FOXM1 a new therapeutic target of extramammary Paget disease Epigenomic analyses identify FOXM1 as a key regulator of anti tumor immune response in esophageal adenocarcinoma FOXM1 Participates in Trophoblast Migration and Early Trophoblast Invasion Potential Role in Blastocyst Implantation

FOXM1 A key oncofoetal transcription factor in health and